Reagents

Biological Reagents

Consumables

Consumables

Instruments

Flow Cytometers

Culture Dishes

Culture Dishes

CD3 GITC
CD3 GITC

FLUOROCHROMES PACIFIC BLUE, FITC, PE, PE-DY594, PERCP, APC, ALEXA FLUOR 700, OC515, CF-BLUE, DY634, APC-C750.

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

logosm-biog
16 Evripidou street, 56224 Thessaloniki

Thessaloniki office tel:   +30 2310 558 888  
Thessaloniki office fax:  +30 2310 558 888

Thessaloniki office e-mail 1:  This email address is being protected from spambots. You need JavaScript enabled to view it.
Thessaloniki office e-mail 2:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Athens office tel: +30 6956 768 939 
Athens office e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.  

Company location