Reagents

Biological Reagents

Consumables

Consumables

Instruments

Flow Cytometers

Culture Dishes

Culture Dishes

CD11C MONOCLONAL ANTIBODY
CD11C MONOCLONAL ANTIBODY
FLUOROCHROMES PACIFIC BLUE, FITC, PE, PERCP, PERCP-CY5.5, PE-CY7, APC CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.

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